Figure 3 | Scientific Reports

Figure 3

From: FOXA1, GATA3 and PPARɣ Cooperate to Drive Luminal Subtype in Bladder Cancer: A Molecular Analysis of Established Human Cell Lines

Figure 3

Comparison of bladder TCGA and CCLE urothelial cancer cell line data identifies parallels in differential expression of transcription factors in human cancers and bladder cancer cell lines, respectively.

Transcription factors differentially expressed between luminal and basal human bladder cancers in TCGA data and CCLE data sets. (A) TCGA data set - top 50 differentially expressed genes (q < 0.1, t-statistic from linear models; all fold-change > 1,000). (B) CCLE data set – 34 genes differentially expressed between luminal and basal cell lines (q < 0.1, t-statistic from linear models; genes drawn from list of genes differentially expressed in TCGA data set).

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