Table 2 Comparison of clinical characteristics between the cerebral microbleeds (+) group and (−) group.
Variable | Cerebral microbleeds | |
|---|---|---|
− (n = 206) | + (n = 73) | |
n (%) | n (%) | |
Clinical characteristics | ||
Age (years) ± SD | 69.5 ± 5.9 | 70.2 ± 6.5 |
Age (range) | 59–89 | 54–87 |
Sex (Male) | 140 (68) | 49 (67) |
BMI (kg/m2) ± SD | 22.5 ± 2.7 | 23.4 ± 3.6* |
Hypertension | 102 (50) | 43 (59) |
Hyperlipidemia | 118 (57) | 47 (64) |
Diabetes mellitus | 27 (13) | 8 (11) |
History of stroke | 2 (1.0) | 3 (4.1) |
History of cardiovascular disease | 8 (3.9) | 6 (8.2) |
Antiplatelet therapy | 17 (8.3) | 12 (16) |
Anticoagulant therapy | 7 (3.4) | 4 (5.5) |
Drinking | 140 (68) | 41 (56) |
Smoking | 26 (13) | 5 (6.8) |
Education ≤12 yearsa | 108 (53) | 42 (60) |
baPWV (m/s) ± SD | 1728 ± 306.9 | 1760 ± 298.9 |
hs-CRP ≥ 0.1 mg/dL | 55 (27) | 22 (30) |
Dental check-up findings | ||
Number of remaining teeth ± SD | 22.9 ± 7.2 | 22.3 ± 8.3 |
Dental caries+ | 60 (29) | 26 (36) |
CPI ≥ code 3 | 50 (24) | 27 (37)* |
Laboratory evaluations | ||
APOE ε4 allele carrierb | 46 (23) | 12 (17) |
Streptococcus mutans-isolated | 192 (93) | 69 (95) |
cnm-positive S. mutans-isolated | 37 (18) | 54 (74)** |
Collagen binding activity ≥10% | 28 (14) | 43 (59)** |
Brain MRI findings | ||
Distribution of CMBs | ||
Deep (%) | — | 44 (60) |
Lobar (%) | — | 20 (27) |
Mixed (%) | — | 9 (12) |
PVH ≥ grade 2 | 24 (12) | 11 (15) |
DWMH ≥ grade 2 | 50 (24) | 27 (37)* |
Cognitive functional evaluations | ||
MMSE (score) ± SD | 28.5 ± 2.2 | 27.9 ± 2.0* |
Letter fluency tasks | ||
“Ta” (score) ± SD | 8.5 ± 3.5 | 7.6 ± 2.9* |
“Ka” (score) ± SD | 10.0 ± 3.5 | 9.2 ± 3.0 |
