Table 4 Comparison of characteristics between cnm-positive Streptococcus mutans (+) group and (−) group and background of collagen binding activity between the (+) group and the (−) group.
Variable | cnm-positive S. mutans-isolated | Collagen binding activity ≥10% | ||
|---|---|---|---|---|
− (n = 188) | + (n = 91) | − (n = 208) | + (n = 71) | |
n (%) | n (%) | n (%) | n (%) | |
Clinical characteristics | ||||
Age (years) ± SD | 70.1 ± 6.1 | 68.9 ± 5.9 | 70.0 ± 6.1 | 69.1 ± 6.0 |
Age (range) | 54–89 | 60–87 | 54–89 | 60–87 |
Sex (Male) | 132 (70) | 57 (63) | 144 (69) | 45 (63) |
BMI (kg/m2) ± SD | 22.6 ± 2.5 | 23.0 ± 3.6 | 22.6 ± 2.7 | 23.0 ± 3.6 |
Hypertension | 94 (50) | 51 (56) | 105 (51) | 40 (56) |
Hyperlipidemia | 108 (57) | 57 (63) | 123 (59) | 42 (59) |
Diabetes mellitus | 25 (13) | 10 (11) | 28 (14) | 7 (9.9) |
History of stroke | 4 (2.1) | 1 (1.1) | 4 (1.9) | 1 (1.4) |
History of cardiovascular disease | 7 (3.7) | 7 (7.7) | 9 (4.3) | 5 (7.0) |
Antiplatelet therapy | 17 (9.0) | 12 (13) | 21 (10) | 8 (11) |
Anticoagulant therapy | 8 (4.3) | 3 (3.3) | 9 (4.3) | 2 (2.8) |
Drinking | 129 (69) | 52 (57) | 123 (59) | 42 (59) |
Smoking | 24 (13) | 7 (7.7) | 12 (5.8) | 4 (5.6) |
Education ≤12 yearsa | 102 (55) | 48 (55) | 112 (55) | 38 (54) |
baPWV (m/s) ± SD | 1728 ± 292.5 | 1755 ± 329.5 | 1728 ± 298.3 | 1761 ± 323.6 |
hs-CRP ≥ 0.1 mg/dL | 49 (26) | 28 (31) | 52 (25) | 25 (35) |
Dental check-up findings | ||||
Number of remaining teeth ± SD | 22.7 ± 7.5 | 22.8 ± 7.4 | 22.7 ± 7.5 | 22.8 ± 7.4 |
Dental caries+ | 52 (28) | 34 (37) | 52 (25) | 34 (48)** |
CPI ≥ code 3 | 48 (26) | 29 (32) | 56 (27) | 21 (30) |
Laboratory evaluations | ||||
APOE ε4 allele carrierb | 40 (22) | 18 (20) | 44 (22) | 14 (20) |
Collagen binding activity ≥10% | — | 71 (78) | — | — |
Brain MRI findings | ||||
CMBs | 19 (10) | 54 (59)** | 30 (14) | 43 (61)** |
Distribution of CMBs | ||||
Deep (%) | 6 (32) | 38 (70)** | 15 (50) | 29 (67)** |
Lobar (%) | 11 (58) | 9 (17) | 13 (43) | 7 (16) |
Mixed (%) | 2 (11) | 7 (13) | 2 (6.7) | 7 (16) |
PVH ≥ grade 2 | 24 (13) | 11 (12) | 26 (13) | 9 (13) |
DWMH ≥ grade 2 | 51 (27) | 26 (29) | 56 (27) | 21 (30) |
Cognitive functional evaluations | ||||
MMSE (score) ± SD | 28.4 ± 2.2 | 28.3 ± 2.0 | 28.3 ± 2.3 | 28.5 ± 1.8 |
Letter fluency tasks | ||||
“Ta” (score) ± SD | 8.4 ± 3.6 | 8.0 ± 2.8 | 8.5 ± 3.5 | 7.6 ± 2.8** |
“Ka” (score) ± SD | 10.1 ± 3.4 | 9.2 ± 3.2* | 10.1 ± 3.4 | 8.9 ± 3.3** |
