Figure 1 | Scientific Reports

Figure 1

From: Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis

Figure 1

Relationship between Nrf2 and EMT in BLM-induced PF.

Nrf2 knockout mice and wild-type mice were treated with BLM (4.5 mg/kg) or saline on days 7, 14 and 28. (A): Pulmonary tissue sections were stained with H&E and Masson’s trichrome to detect the histopathological structure and collagen accumulation respectively. Scale bars represent 20 μm. (B): Relative protein expression of Nrf2, E-cadherin, α-SMA and SPC was measured by IHC. Scale bars represent 20 μm. Histogram bars represent means ± SD (n = 4–6 per group). **P < 0.01 compared with WT saline group, ##P < 0.01 compared with Nrf2−/− saline group, +P < 0.05, ++P < 0.01 compared with WT BLM group.

Back to article page