Figure 1
From: Structural Basis for Human PECAM-1-Mediated Trans-homophilic Cell Adhesion
Overall structure of PECAM-1 IgL1-2 trans-homophilic dimer.
(A) Front and back views of the IgL1-2 trans-homophilic dimer structure in which IgL1 and IgL2 are labeled with blue and red colors respectively. IgL1 interacts with IgL2 from the opposite monomer. Both IgL1 and IgL2 hold a traditional immunoglobulin conformation that consists of two β-sheet layers anchored by one disulfide bond. (B) Hydrophobic and hydrophilic surface of an IgL1-2 monomer. Hydrophobicity surfaces are presented by Chimera with orange red for most hydrophobic and dodger blue for most hydrophilic33. The two interface regions of the IgL1-2 dimerization are highlighted by two black ellipses. Hydrophobic areas are concentrated at the center of each region and hydrophilic areas form two circumambient barriers that surround hydrophobic centers.
