Figure 4
From: Structural Basis for Human PECAM-1-Mediated Trans-homophilic Cell Adhesion
Mutational analysis on PECAM-1 mediated cell adhesion.
Compared to negative control (NeCon) group, both wildtype (WT) and glyco-mutated (GlycoM, N52Q/N84Q/N151Q) PECAM-1 can significantly increase cell junction among HEK293 cells. Functional mutation (FunM, L74E/I112E/F188E/I190E) on PECAM-1 can decrease the probability of cell contact. (**P < 0.005; ***P < 0.0005; ns: non-significant).
