Figure 1 | Scientific Reports

Figure 1

From: Sexual dimorphic function of IL-17 in salivary gland dysfunction of the C57BL/6.NOD-Aec1Aec2 model of Sjögren’s syndrome

Figure 1

Loss of IL-17 restores normal secretory function of the salivary glands.

Stimulated saliva were collected and measured. (A) Restored normal saliva flow of male and female mice. The saliva flow rate for males, females and males with females (SFR ± SEM, presented as μL/gram/10 min) is shown from 4–28 weeks of age (B6 F, n = 8; B6 M, n = 7; B6.Il17−/− F, n = 5; B6.Il17−/− M, n = 5; B6.NOD-Aec1Aec2 F, n = 7; B6.NOD-Aec1Aec2 M, n = 6; B6.NOD-Aec1Aec2.Il17−/− F, n = 5; B6.NOD-Aec1Aec2.Il17−/− M, n = 10) for males. The statistical differences were determined using one-way ANOVA where **p < 0.005, ***p < 0.001 and ****p < 0.0001. (B) Normal saliva flow at advanced age in males and females. The percentage of the loss of SFR between the 4-week and 28-week time points is displayed ± SEM for males, females and males with females. The statistical differences were determined using one-tailed unpaired t-test with Welch’s correction (NS: not significant, *p < 0.05, **p < 0.01, and ***p < 0.001).

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