Table 2 Regression analysis of reported telomere length related loci with relative telomere length (RTL) among pregnant women and newborn.

From: The known genetic loci for telomere length may be involved in the modification of telomeres length after birth

Locus [reference]

Chr.

Associated gene

Reported effect allelea

Alternative allele

Maternal genotype and RTLb

Cord genotype and RTLb

EAFc

β

P

EAF

β

P

rs1093659919

3q26.2

TERC

T

C

0.574

−0.0119

0.041

0.566

−0.0017

0.819

rs1112552919

2p16.2

ACYP2

C

A

0.811

0.0019

0.792

0.825

−0.0012

0.892

rs273610019

5p15.33

TERT

T

G

0.570

−0.0110

0.046

0.594

0.0052

0.470

rs273610822

5p15.33

TERT

G

A

0.684

−0.0080

0.176

0.722

−0.0020

0.799

rs438728721

10q24.33

OBFC1

C

A

0.840

−0.0027

0.725

0.847

−0.0010

0.920

rs75501719

20q13.33

RTEL1

A

G

0.590

−0.0017

0.779

0.573

0.0023

0.736

rs767599819

4q32.2

NAF1

A

G

0.155

−0.0054

0.493

0.159

−0.0005

0.958

rs810576719

19p12

ZNF208

A

G

0.711

0.0061

0.307

0.719

−0.0002

0.978

  1. aThe reported effect allele associated with short telomeres in populations of European descent.
  2. bDerived from generalized linear models. The reference homozygotes, heterozygotes and effect homozygotes were encoded as 0, 1 and 2, respectively.
  3. cEAF: Effective allele frequency.