Figure 5
From: HOPX functions as a tumour suppressor in head and neck cancer
Tumour suppressive effects of HOPX in OSCC and NPC cells.
The proliferation (A), plating efficiency (B) and migration (C) of HOPX expressing H376 OSCC and HONE1 NPC cells was significantly reduced compared to vector transfected controls. HOPX expressing H376 and HONE1 cells were more sensitive to DNA damage induced by UVA irradiation as determined by the percentage of floating cells in the culture dish (D) after 24 hours and enhanced in apoptosis as determined by flow cytometric analysis of Annexin V staining 24 hours after irradiation (3 J/cm2 UVA; E). Results are shown as mean ± SD values of triplicates. *ρ < 0.05, **ρ < 0.01 and ***ρ < 0.001.
