Figure 7
From: A genome-wide screen of bacterial mutants that enhance dauer formation in C. elegans
Model of how bacterial cAMP signaling regulates dauer formation and lifespan in worms.
Lack of bacterial cAMP inhibits the expression of DAF-7, resulting in the inhibition of DAF-3/5. This leads to the suppression of IGF-1 pathway in animals, and enhances the dauer formation and lifespan extension in DAF-16/FOXO dependent manner.
