Figure 2 | Scientific Reports

Figure 2

From: Changes in hippocampal AMPA receptors and cognitive impairments in chronic ketamine addiction models: another understanding of ketamine CNS toxicity

Figure 2

Spatial working memory performance of mice in Radial Arm Maze tests following three and six months of ketamine administration with different doses of ketamine 30 mg/kg and 60 mg/kg.

(A) Significant increase of total errors were seen in K2 60 mg/kg comparing with Control 2 (*p < 0.05). (B) Significant increase of time spent in one session to accomplish a Radial Arm Maze test in K2 60 mg/kg comparing with Control 2 and K2 60 mg/kg comparing with K1 60 mg/kg (*p < 0.05, #p < 0.05). (C) Representative searching tracks of mice with different treatments in the Radial Arm Maze tests acquisition trails. Control 1 n = 23, K1 30 mg/kg n = 24, K1 60 mg/kg n = 25, Control 2 n = 23, K2 30 mg/kg n = 24, K2 60 mg/kg n = 25.

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