Figure 1
Flowchart of sample selection from ¹the randomized-controlled trial (rct) of the effect of different micronutrient (MN) supplementation on top of anti-tuberculosis therapy (ATT).
As part of the ATT rct, included children were assigned to 4 intervention groups; micronutrient supplementation (MN) with or without zinc (Zn), Zn alone or placebo, and followed for 6 months10. Samples available for transcriptional biomarker studies from each intervention-group at baseline, and after 2 and 6 months of treatment are depicted in the table. *The sampling for the present biomarker study were possible after approval of a study amendment during the on-going inclusion to the mother study. Participation in the present add-on study required an additional consent at each study visit for additional biomarker study-specific blood-draws. This explains why 88 and not all of the 99 children have a baseline sample, and the successive loss of available samples for transcriptional biomarker studies. Altogether, 163 samples were available. The distribution of samples at baseline, and after 2 and 6 months of treatment from each intervention group, are depicted in the table for clarity.
