Table 2 Associations between baseline measurements of each of the 11 biomarkers (BM) that consitently changed with ATT and the extent of TB disease at the time of diagnosis (before the initiation of treatment).

BM change with treatment	BM entered in the model	Smear positivityˇ		Mtb culture positive°		Cavitating disease		Body Mass Index Z-score <−2		Body Mass Index Z-score, continous scale		Association with treatment outcomes
BM change with treatment	BM entered in the model	OR	95% CI for OR	OR	95% CI for OR	OR	95% CI for OR	OR	95% CI for OR	Rho	p	2 months	6 months
Decrease	FCGR1A	ns		3,14	(1,584–6,21)	ns		ns		ns		YES^a	YES^a
	FPR1	9,78	(2,09–45,8)	ns		ns		2,83	(1,13–7,14)	ns		ns	ns
	MMP9	ns		1,44	(1,02–2,03)	1,82	(1,06–3,12)	ns		–0,24	0,024	ns	ns
Increase	BCL2	0,3	(0,1–0,92)	ns		0,12	(0,03–0,49)	ns		ns		ns	ns
	BLR1	0,47	(0,32–0,70)	0,46	(0,28–0,74)	0,5	(0,33–0,74)	ns		0,24	0,026	YES^b	ns
	CASP8	ns		ns		0,13	(0,03–0,68)	ns		ns		ns	ns
	CD3E	0,42	(0,23–0,78)	0,55	(0,33–0,92)	0,38	(0,20–0,75)	ns		0,23	0,037	ns	ns
	CD4	0,37	(0,18–0,78)	ns		0,45	(0,23–0,88)	ns		ns		ns	ns
	CD19	ns		ns		ns		ns		0,22	0,043	ns	ns
	IL7R	0,25	(0,11–0,56)	0,38	(0,21–0,69)	0,22	(0,09–0,53)	ns		0,22	0,04	ns	ns
	TGFBR2	0,22	(0,05–0,94)	0,11	(0,03–0,37)	0,02	(0,003–0,19)	ns		ns		ns	ns

Of 2 induced sputum samples and 2 gastric aspirate samples taken on 2 consecutive days at least ˇone specimen positive for acid-fast bacilli, °one culture samples with growth of Mycobacterium tuberculosis. ^a2-month FCGR1A-value; positive association, details given in the text. ^bBaseline BLR1-value; negative association, and change from BL to 2 months; positive association, details given in the text.
Unadjusted odds ratio estimates and 95% confidence intervals is given for categorical variables and Spearman’s Rho and corresponding p-value is given for continous variables. ns signifies non-significant associations.

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