Table 1 Properties of rPrP variants.
From: The role of the unusual threonine string in the conversion of prion protein
Protein | PMCA Successful PMCA/total No. of PMCA | Amyloid fibril De novo growth | Amyloid fibril Seeded growth | Tm (˚C) (± SD) |
|---|---|---|---|---|
PrPa | 20/20 | +++ | +++ | 78.8 ± 3.5 |
PrPb | 0/20 | + | + | 74.1 ± 2.2 |
L108F* | 0/20 | +++ | +++ | 69.6 ± 2.1 |
T189V* | 0/20 | + | + | 69.6 ± 1.6 |
T191A* | 5/20 | +++ | +++ | 70.3 ± 1.1 |
T191V* | 12/20 | +++ | +++ | 69.4 ± 2.2 |
T191P* | 0/20 | + | +++ | 74.3 ± 0.9 |
