Figure 1

Amino acid fingerprints associated with signal perception by members of the CsoR/RcnR family and amino acid sequences of EcFrmR and StyFrmR.

(a) Amino acid residues in the W-X-Y-Z fingerprint of CsoR/RcnR family proteins and the signals perceived by the indicated proteins. (b) Alignment of the E. coli (Ec) and S. enterica serovar Typhimurium (Sty) FrmR proteins. Identical (single letter code) and similar (+) residues, Pro2 (brown background), Cys35 and Cys70 (yellow background) are indicated. Residues of the W-X-Y-Z fingerprint (blue font) are indicated. Position W is shown to incorporate both Pro2 and Ser/His3 (as indicated by parentheses; see text for details). Residues on blue backgrounds have been implicated in DNA-binding in other CsoR/RcnR family members.