Figure 6
From: Pleiotropic Effects of Myocardial MMP-9 Inhibition to Prevent Ventricular Arrhythmia
Mechanisms of MMP-9 inhibition to prevent ventricular arrhythmia.
MMP-9 does not change collagen and Cx43 production but increases Cx43 lateralization. These minor changes might not significantly alter the conduction heterogeneity. In addition, MMP-9 can act as an intracellular signal regulator through the degradation of CD36 and increase calcium leakage, ventricular triggers, and arrhythmia through PKA and the hyperphosphorylation of RyR2.
