Figure 11 | Scientific Reports

Figure 11

From: Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D

Figure 11

SM significantly decreased mitochondrial membrane potential.

(A) Fluorescence image of worms were stained by JC-1 at 20 °C for 20 min (N = 20). C: control. CsA, 5 μM Cyclosporin A; CCCP, 10 μM Carbonyl cyanide 3-chlorophenylhydrazone, positive control. Scale bar, 200 μm. (B) Quantified fluorescence intensity of JC-1 of each group. Data is presented as the mean ± SD of at least three independent experiments. Bars with different letters indicated that there was a significant difference at a level of 0.05 among groups.

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