Figure 15 | Scientific Reports

Figure 15

From: Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D

Figure 15

The effect of cep-1, jnk-1 and pmk-1 RNAi on the Muv phenotype in let-60 (gf) mutants.

1 mg/mL RNAi bacteria was added to per well and treated the worms for 3–4 days (N = 80–100). HT115 containing empty L4440 was fed as a control. p53, JNK, and p38/MAPK pathway are involved in SM down regulating over-activated Ras. Data is presented as the mean ± SD of at least three independent experiments. Bars with different letters indicated that there was a significant difference at a level of 0.05 among groups.

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