Figure 16 | Scientific Reports

Figure 16

From: Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D

Figure 16

SM inhibited ERK downstream of Ras, and CEP-1 was involved in SM suppressing over-activated Ras/MAPK pathway.

(A) The effect of SM on ERK1/2, p- ERK1/2 and CEP-1 in let-60(gf) mutants. Quantification of CEP-1 (B), ERK1/2 (C), p-ERK1/2 (D) band intensities, which were normalized using GAPDH blots. L, C, J, P, LS, CS, JS and PS were groups treated by RNAi of L4440, cep-1, jnk-1, pmk-1, L4440 + SMH, cep-1 + SMH, jnk-1 + SMH and pmk-1 + SMH, respectively. Data is presented as the mean ± SD of at least three independent experiments. Bars with different letters indicated that there was a significant difference at a level of 0.05 among groups.

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