Figure 6 | Scientific Reports

Figure 6

From: Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D

Figure 6

SM significantly increased the level of superoxide in let-60 (gf) mutants.

(A) Fluorescence image of worms after stained by 5 μM MitoSox at 20 °C for 20 min (N = 20). Con and C: control. NAC, 2.5 mM N-Acety-L-Cysteine; PQ, 0.5 mM paraquat. SOD, 150 U superoxide dismutase. Scale bar, 200 μm. (B) Quantified fluorescence intensity of MitoSox of each group. Worms treated by SM had a brighter fluorescent level. Data is presented as the mean ± SD of at least three independent experiments. Bars with different letters indicated that there was a significant difference at a level of 0.05 among groups.

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