Table 2 IC50 values, inhibition kinetics, and inhibitory constants of the theaflavins against DXR.

From: Antimicrobial mechanism of theaflavins: They target 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway

 

IC50 (μM)

NADPH

DXP

Ki (μM)

Kinetics

Ki (μM)

Kinetics

TF

162.1 ± 3.6

83.1 ± 4.3

 

107.3 ± 3.9

 

TF3G

29.2 ± 2.6

24.7 ± 3.2

 

30.2 ± 2.6

 

TF3′G

23.7 ± 2.9

22.4 ± 2.1

Uncompetitive

22.2 ± 3.1

Noncompetitive

TF3,3′G

14. 9 ± 2.1

18.2 ± 2.3

 

13.3 ± 2.4

 

Fosmidomycin

0.27 ± 0.06

    
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