Figure 5
From: Ester-Modified Cyclometalated Iridium(III) Complexes as Mitochondria-Targeting Anticancer Agents
(A) Loss of MMP in A549 cells treated with 4a or 4b. Cells were incubated with Ir(III) complexes at the indicated concentrations for 6 h and then stained with JC-1. JC-1 was excited at 488 nm and monitored simultaneously at 515‒545 nm (Green) and 575‒605 nm (Red). (B) Depletion of cellular ATP levels in A549 cells treated with 4a or 4b. Cells were incubated with 4a or 4b at the indicated concentrations for 6 h. The luminescence intensity was measured by a microplate reader. **p < 0.02.
