Table 1 IC50 values of Ir(III) complexes towards different cell lines in vitro.

From: Ester-Modified Cyclometalated Iridium(III) Complexes as Mitochondria-Targeting Anticancer Agents

Complex

IC50 (μM)a

HeLa

A549

A549R

HepG2

MCF-7

1a

>100

>100

>100

>100

>100

2a

35.1 ± 2.7

>100

77.6 ± 3.0

>100

68.4 ± 2.5

3a

15.8 ± 1.3

13.9 ± 1.2

9.1 ± 1.0

19.5 ± 1.7

23.5 ± 2.2

4a

2.1 ± 0.2

1.7 ± 0.1

2.1 ± 0.2

5.5 ± 0.4

5.3 ± 0.6

5a

2.2 ± 0.2

1.9 ± 0.2

2.2 ± 0.3

4.8 ± 0.4

3.4 ± 0.4

1b

>100

>100

>100

>100

>100

2b

24.6 ± 1.2

10.5 ± 1.0

10.2 ± 0.9

20.9 ± 1.9

35.2 ± 2.3

3b

7.3 ± 0.6

16.8 ± 1.2

14.1 ± 1.2

12.0 ± 1.1

19.5 ± 1.0

4b

1.9 ± 0.1

2.3 ± 0.2

1.7 ± 0.1

2.5 ± 0.2

4.3 ± 0.4

5b

2.4 ± 0.2

5.8 ± 0.4

2.7 ± 0.2

4.3 ± 0.3

8.4 ± 0.7

cisplatin

25.1 ± 2.2

23.7 ± 1.0

79.4 ± 6.1

15.8 ± 1.2

16.8 ± 1.5

  1. aIC50 values are drug concentrations necessary for 50% inhibition of cell viability. Data are presented as means ± standard deviations obtained in at least three independent experiments.
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