Table 1 MIC values (μg/mL) of compounds against a panel of bacteria.

From: Unusual dimeric tetrahydroxanthone derivatives from Aspergillus lentulus and the determination of their axial chiralities

Compounda

Sa1c

Sa2c

MRSAc

MRSEc

Pa c

Kp c

Ab c

1

6.8 ± 0.6

>100

38.5 ± 4.3

31.5 ± 3.7

>100

62.8 ± 4.0

63.2 ± 6.3

2

4.7 ± 0.6

84.1 ± 9.9

65.8 ± 3.9

65.7 ± 6.0

35.8 ± 4.5

>100

>100

3

5.5 ± 0.4

3.1 ± 0.3

29.3 ± 2.3

31.3 ± 3.4

8.0 ± 0.6

59.1 ± 5.1

60.1 ± 4.2

5

13.3 ± 1.5

>100

62.5 ± 5.3

>100

>100

>100

>100

6

10.6 ± 0.4

40.2 ± 0.9

>100

>100

19.3 ± 0.6

>100

>100

penicillinb

0.5 ± 0.05

71.2 ± 6.0

     

streptomycinb

    

0.6 ± 0.03

  

tigecyclineb

  

0.5 ± 0.03

0.7 ± 0.04

 

0.5 ± 0.05

0.6 ± 0.03

  1. aThe compounds were inactive when MICs > 100 μg/mL, ±SD values were calculated on three individual experiments.
  2. bPositive control.
  3. cSa1, Staphylococcus aureus ATCC 25923; Sa2, S. aureus clinical strain; Pa, Pseudomonas aeruginosa ATCC 9027; Kp, Klebsiella pneumonia clinical strain; Ab, Acinetobacter baumannii clinical strain.
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