Figure 1 | Scientific Reports

Figure 1

From: Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

Figure 1

(a) Newly identified anti-mycobacterial compounds that target the essential inosine monophosphate dehydrogenase, GuaB2 (JAGC_1–7). These molecules have been identified in a target-based HTS using M. bovis BCG over-expressing GuaB2 from Mtb. Chemical structures of the DPU compounds (DPU-1-3) are also shown (boxed)13. Details of the chemical data for JAGC_1–7 is provided in Supplementary Table 1. (b) Graph illustrating the difference in XC50 (compound concentration required to inhibit cell viability by 50%) of each compound against M. bovis BCG pMV261 and M. bovis BCG pMV261-guaB2. (c) Graph showing the percentage biochemical inhibition of GuaB2 by JAGC_1–7 respectively, with isoniazid (INH) and an optimized diphenyl urea compound (DPU-2), as respective negative and positive controls.

Back to article page