Figure 1 | Scientific Reports

Figure 1

From: Anticancer activity of a monobenzyltin complex C1 against MDA-MB-231 cells through induction of Apoptosis and inhibition of breast cancer stem cells

Figure 1

(a) Histological sections of liver and kidney. Histology (hematoxylin and eosin stain, 20×) of the liver (A–D) and kidney (E–H) did not show any abnormality after treatment with (B and F) 25 mg/kg, 50 mg/kg (C and G), and 100 mg/kg (D and H) of compound C1 compared to the vehicle distilled water (A and E). (b) AO/PI staining of untreated and treated MDA-MB-231 cells with the IC50 concentration of compound C1 (2.5 μg/mL) after 48 hours: (A) Untreated cells, which display VI: viable cells; (B) treated cells, which display EA: early apoptotic cells, LA: late apoptotic cells, N: necrotic cells. (c) Lactate dehydrogenase (LDH) assay: Significant release of LDH in the cell culture medium after treatment of MDA-MB-231 cells with different concentrations of benzyltin complex C1 for 48 hours.

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