Figure 6 | Scientific Reports

Figure 6

From: Anticancer activity of a monobenzyltin complex C1 against MDA-MB-231 cells through induction of Apoptosis and inhibition of breast cancer stem cells

Figure 6

(a and b) Quantitative study of apoptosis markers gene expression. The expression of Bax (a) and Bcl2 (b) mRNA in MDA-MB-231 cells treated with 2.5 μg/mL (IC50) of compound C1 after 24, 48, and 72 hours. The results revealed a significant elevation and decrease in expression of Bax and Bcl2 genes. (c) Western blot analysis of apoptotic pathway hallmarks: Treatment with 2.5 μg/mL (IC50) of compound C1 after 24, 48, and 72 hours increased protein expression levels of Bax, and decreased Bcl2, and HSP70. The data represent the means ± standard deviations (SDs) of 3 independent tests. Statistical analysis is defined as significant if *P < 0.05.

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