Figure 1 | Scientific Reports

Figure 1

From: A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism

Figure 1

(A) The chemical structure of lefamulin. (B) The weighted 2Fo-Fc electron density map of the complex S50S-lefamulin around the lefamulin’s binding site contoured at 1.0σ. (C) The binding site of lefamulin (green) within the SA50S-lef structure at the PTC (D) Zoom into the binding pocket where lefamulin (green) is held within the PTC 23S rRNA nucleotides (orange) with hydrogen bonds (dashed lines). The U:U interactions between U2585 and U2506 stabilize the lefamulin binding pocket.

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