Figure 3
From: A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism
Inhibition of bacterial protein synthesis.
The inhibitory effect of BC-3205, lefamulin and tiamulin on protein expression in S. aureus in vitro transcription-translation cell-free system. The activity of the reporter protein (luciferase) in the presence of various concentrations of BC-3205, lefamulin and tiamulin is shown as arbitrary unit of luminescence [a.u.]. The IC50 values calculated by the plotted data showed better inhibition of protein synthesis by lefamulin than by BC-3205 and tiamulin.
