Figure 4 | Scientific Reports

Figure 4

From: The Identification and Characterization of Two Novel Epitopes on the Nucleocapsid Protein of the Porcine Epidemic Diarrhea Virus

Figure 4

Amino acid sequence analysis of the two identified epitopes among different virus strains.

(a) Amino acid sequence alignments of NEP-D4 and NEP-D6 from 23 PEDV representative strains, including 4 classical strains and 19 currently circulating strains. (b) Similarly, residues 18–133 and residues 252–262 of 21 Alphacoronavirus strains, including seven PEDV strains, six TGEV strains, two human coronavirus 229E strains, two human coronavirus NL63 strains, two PRCV (porcine respiratory coronavirus) strains and two FIPV (feline infectious peritonitis virus) strains, 6 Betacoronavirus strains, including two SARS-CoV (severe acute respiratory syndrome coronavirus) strains, two MERS-CoV (Middle East respiratory syndrome coronavirus) strains and two MHV (mouse hepatitis virus) strains, 2 IBV (Infectious bronchitis virus) strains from Gammacoronavirus, and 3 PDCoV (porcine deltacoronavirus) strains from Deltacoronavirus, were selected for alignment. The corresponding antigenic positions of NEP-D4 and NEP-D6 of all strains are colored green and red, respectively. PEDV strains FJzz1/2011 and HLJ/2011 isolated from our laboratory were marked with black triangles. The major mutations are highlighted by dotted frames.

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