Figure 6

Predicted 3D structural model of N protein with Phyre2.

The N protein 3D model was visualized using the PyMOL molecular graphics and modeling system and was viewed from the side (a) and top (c). The protein epitope domains identified in this study are highlighted in different colors. (b) The conformation of the epitope NEP-D6 is displayed with all residues indicated in the corresponding positions. (d) The secondary structure of epitope NEP-D4 is depicted, in which the predicted disordered regions are colored green and tertiary structures showing PIDR1^{18,19,20,21,22}, PIDR2^107–116 and PIDR3^127–133 are colored blue, magenta and red, respectively. (e,f) The putative spatial positions of critical residues, E¹³³ and L¹⁸, which are represented by orange. (g) The sequence of N protein with alpha helixes, beta strands and PIDRs. (h) Template coverage used in the structure modeling.