Table 1 Demographic and clinical features of RCC patients and control subjects in the discovery and validation sets.
Characteristics | Discovery set (N, %) | Validation set (N, %) | Combined set (N, %) | P a | |||
|---|---|---|---|---|---|---|---|
Case | Controls | Case | Controls | Case | Controls | ||
Overall | 355 | 362 | 672 | 732 | 1027 | 1094 | |
Age (mean ± SD) | 57.1 ± 11.8 | 56.4 ± 13.1 | 56.5 ± 12.2 | 57.5 ± 11.4 | 56.7 ± 12.1 | 57.1 ± 12.1 | 0.522 |
Gender | |||||||
Male | 228 (64.2) | 212 (58.6) | 424 (63.1) | 492 (66.1) | 652 (63.5) | 704 (64.4) | 0.678 |
Female | 127 (35.7) | 150 (41.4) | 248 (36.9) | 240 (33.9) | 375 (36.3) | 390 (35.6) | |
Smoking status | |||||||
Never | 220 (62.0) | 242 (66.9) | 427 (63.5) | 501 (68.4) | 647 (63.0) | 743 (67.9) | 0.017 |
Former | 135 (38.0) | 120 (33.1) | 245 (36.5) | 231 (31.6) | 380 (37.0) | 351 (32.1) | |
Drinking status | |||||||
Never | 249 (70.1) | 248 (68.5) | 501 (74.6) | 559 (76.4) | 750 (73.0) | 807 (73.8) | 0.701 |
Ever | 106 (29.9) | 114 (31.5) | 171 (25.4) | 173 (23.6) | 277 (27.0) | 287 (26.2) | |
Hypertension | |||||||
No | 220 (62.0) | 255 (70.4) | 406 (60.4) | 555 (75.8) | 626 (70.0) | 810 (74.0) | <0.001 |
Yes | 135 (38.0) | 107 (29.6) | 266 (39.6) | 177 (24.2) | 401 (30.0) | 284 (26.0) | |
Diabetes | |||||||
No | 310 (87.3) | 345 (95.3) | 585 (87.0) | 682 (93.2) | 895 (87.2) | 1027 (93.9) | <0.001 |
Yes | 45 (12.7) | 17 (4.7) | 87 (13.0) | 50 (6.8) | 132 (12.8) | 67 (6.1) | |
Clinical stage | |||||||
I | 227 (63.9) | 444 (66.1) | 671 (65.3) | ||||
II | 63 (17.7) | 137 (20.4) | 200 (19.5) | ||||
III | 21 (5.9) | 52 (7.7) | 73 (7.1) | ||||
IV | 44 (12.4) | 39 (5.8) | 83 (8.1) | ||||
Grade | |||||||
I | 68 (19.2) | 155 (23.1) | 222 (21.6) | ||||
II | 170 (47.9) | 355 (52.8) | 525 (51.1) | ||||
III | 84 (23.7) | 128 (19.1) | 213 (20.7) | ||||
IV | 33 (9.3) | 34 (5.1) | 67 (6.5) | ||||
Histology | |||||||
Clear cell | 301 (84.8) | 558 (83.0) | 860 (83.7) | ||||
Papilarry | 8 (2.3) | 29 (4.3) | 36 (3.5) | ||||
Chromophobe | 17 (4.8) | 38 (5.7) | 55 (5.4) | ||||
