Figure 5 | Scientific Reports

Figure 5

From: Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders

Figure 5

Oscillatory activity and immunostaining.

(a) Oscillatory activity of the vmPFC, Nacc and STN in wt (n = 5) and DAT-tg rats (n = 7). Upper panel shows entire frequency range, lower panel shows mean values for the frequency bands: theta (4–8 Hz), alpha (8–12 Hz), beta (12–30 Hz), and gamma (30–100 Hz). (b) Immunohistochemical cell counts of parvalbumin expressing (PV+) cells of the medial prefrontal cortex (mPFC), hippocampus (Hipp), caudate putamen (CPu) and globus pallidus (GP) in wt (n = 12) and DAT-tg rats (n = 11). (c) c-Fos expressing cells on representative slices of the mPFC, orbitofrontal cortex (OFC), nucleus accumbens (Nacc), CPu, GP, Hipp, thalamus (Thal) and subthalamic nucleus (STN) in wt (n = 8) and DAT-tg rats (n = 8). (d) Immunohistochemical cell counts of Ki67 expressing cells in the neurogenic zones of the hippocampus (dentate gyrus, DG) and the subventricular zone (SVZ) in wt (n = 9) and DAT-tg rats (n = 9).

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