Figure 8
Repetitive behavior analysis.
(a) Upper panel left: Repetitive behavior induced by d-amphetamine (0.5, 2.0 and 5.0 mg per kg body weight (BW)). Upper panel right: In DAT-tg rats, repetitive behavior evolves 80–120 min after d-amphetamine (2 mg /kg BW). The wt rats display hyperlocomotion throughout the period (120 min). Hot colors (red) indicate presence and cold colors (blue) absence of behavior. Lower panel: dose-dependent effects of d-amphetamine. (b) Clonidine effects (left) and fluoxetine (right) on locomotion and oral stereotypy following d-amphetamine (2 mg/kg BW) in wt (clonidine: n = 10; fluoxetine: n = 9) and DAT-tg rats (clonidine: n = 9; fluoxetine. n = 8). (c) Effects of quinpirole (QNP) on compulsive checking (left) and grooming behavior (right) in wt (n = 10) and DAT-tg rats (n = 10). All data are means ± s.e.m. Asterisk (*) indicates significant difference to wt rats, paragraph (§) indicates treatment effect (p < 0.05).
