Table 1 Host iron-associated genes differentially regulated during P. aeruginosa infection.

From: Dual-seq transcriptomics reveals the battle for iron during Pseudomonas aeruginosa acute murine pneumonia

Gene name

Description

Fold up-regulated during infection

p-value

Lcn2

Lipocalin 2

30.85

8.34E-04

Ltf

Lactotransferrin

14.34

2.16E-05

Fth1

Ferritin heavy chain 1

6.27

2.33E-03

Cp

Ceruloplasmin

4.82

2.83E-05

Hba-a1

Hemoglobin alpha, adult chain 1

2.11

3.12E-03

Hba-a2

Hemoglobin alpha, adult chain 2

2.96

3.03E-04

Hbb-bs

Hemoglobin beta adult s chain

2.07

1.98E-03

Hbb-bt

Hemoglobin beta adult t chain

2.54

1.89E-04

Steap4

Metalloreductase able to reduce Fe3+ to Fe2+ using NAD+ as receptor

20.64

4.59E-05

Slc39a14

Soluble metal carrier protein

17.85

2.69E-05

Fbxl5

F-box and leucin-rich repeat protein 5, iron sensor

5.72

1.65E-05

Picalm

Phosphatidylinositol binding clathri assembly protein, transferrin receptor internalization

3.74

3.45E-05

Scd2

Stearoyl-coenzyme A desaturase 2, iron binding and oxydoreductase activity

−1.9

5.54E-05

Mmp8

Metallopeptidase 8

34.28

2.57E-05

Mmp9

Metallopeptidase 9

13.82

2.28E-05

  1. Fold changes were calculated by comparing infected to non-infected mice. Fold changes greater than 1 indicate that the gene was up-regulated during infection compared to in vitro growth conditions. Fold changes inferior to −1 indicate that the gene was down-regulated during infection compared to in vitro growth conditions.
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