Figure 6

Radiographic and histological evidence of the bactericidal effect of the TA2-nHP66 scaffold material in experimental osteomyelitis.

(A) Radiographic imaging of experimental osteomyelitis in the course of TA2-nHP66 treatment. (a) Four weeks after the induction of osteomyelitis; (b) After treatment with porous TA2-nHP66 scaffold for 12 weeks (indicated by the arrow); (c) After treatment only with debridement for 12 weeks; (d) After treatment with control nHP66 scaffold for 12 weeks (indicated by the arrow). (B) H & E and Masson trichrome staining of bone-Scaffold interface. The implants were retrieved at 12 weeks and subjected to H & E staining (a–c) and Masson trichrome staining (d–f). (a & d) treatment only with debridement; (b & e) treatment with control nHP66 scaffold material; and (c & f) treatment with TA2-nHP66 scaffold material. Representative results are shown. SM, scaffold material; TB, trabecular bone.