Figure 2 | Scientific Reports

Figure 2

From: An Exceptionally Facile Two-Step Structural Isomerization and Detoxication via a Water-Assisted Double Lossen Rearrangement

Figure 2

DDBQ yields of the reactions of NHPI (derivative) and TCBQ/TrCBQ-OH under different conditions.

(A) NHPI enhanced TCBQ hydrolysis in a concentration-dependent manner. (B) NHPI enhanced TrCBQ-OH hydrolysis in a concentration-dependent manner. (C) NHPI enhanced TCBQ hydrolysis in a pH-dependent manner (TCBQ, 0.2 mM; NHPI, 0.8 mM). (D) O-propargyl NHPI did not enhance TCBQ hydrolysis. All incubation mixtures contained the indicated concentration of NHPI in phosphate buffer (100 mM, pH 7.4) at 37 °C. The reactions were initiated by the addition of TCBQ or TrCBQ-OH (0.2 mM), followed by rapid mixing. DDBQ formation was monitored using the HPLC method.

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