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Figure 1

From: Adjunctive treatment of brexpiprazole with fluoxetine shows a rapid antidepressant effect in social defeat stress model: Role of BDNF-TrkB signaling

Figure 1

Antidepressant effects of combination of brexpiprazole and fluoxetine in social defeat stress model.

(a): Schedule of social defeat stress, treatment, and behavioral tests. Repeated social defeat stress was performed 10 days (day 1- day 10). Social interaction test was performed day 11, and susceptible mice were used subsequent experiments. Vehicle (10 ml/kg), fluoxetine (10 mg/kg), brexpiprazole (0.1 mg/kg), or fluoxetine (10 mg/kg) plus brexpiprazole (0.1 mg/kg) were administered orally. Locomotion (LST), tail-suspension test (TST), and forced swimming test (FST) were performed 2, 4, and 6 hours after oral administration (day 12). One % sucrose preference test (SPT) was performed 24 hours after oral administration (day 13). (b): LMT, (c): TST, (d): FST, (e): SPT. Data are shown as mean ± S.E.M. (n = 6–9). *P < 0.05, **P < 0.01, ***P < 0.001 compared to vehicle-treated stress group (one-way ANOVA, followed post hoc LSD test). N.S.: Not significant.

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