Figure 1
From: Histone deacetylase inhibitors mediate DNA damage repair in ameliorating hemorrhagic cystitis
Bladder inflammation associated with Ogg1 down regulation and DNA damage.
(A), Bladder inflammation was induced in mice by treated with CPX. Bladder inflammation was determined by hematoxylin and eosin (H&E) staining (the scale bar represents 64 μm). Immunohistochemical localization of (B), 8-Oxo-dG and (C), Ogg1 is identified in the detrusor muscle (arrowheads) in control and mouse treated with CPX. The quantitation of the differential staining reached significance (**p value < 0.01; ***p value < 0.001, between groups by student’s T-test, n = 3). The scale bar represents 32 μm. (D) Ogg1 protein expression in bladder tissues was measured by Western blotting with ß-actin loading control. The densitometry of the blots indicate relative expression, normalized to ß-actin and mean fold change over control (n = 3).
