Figure 2
From: Histone deacetylase inhibitors mediate DNA damage repair in ameliorating hemorrhagic cystitis
Down regulation of Ogg1 leads to initiation of pyroptotic cascade.
(A) Caspase 1 was immuno-localized in the detrusor muscle of control and CPX treated mice (arrowheads). There was a significant elevation of caspase 1 staining (scale bare represents 32 μM). The corresponding bar graph illustrate the mean expression of the respective staining (n = 3). (B) Immunoblots for NLRP3, cleaved-caspase1, and active-IL-1ß from mouse bladder detrusor muscle tissues in response to CPX treatment were quantitated relative to ß-actin expression (n = 3). Asterisk (*) indicate a p value < 0.05 between groups by Student’s t-test.
