Figure 4 | Scientific Reports

Figure 4

From: Biological characteristics comparison of HBV rtA181T mutants with truncated or substituted HBsAg expression in vitro and in vivo model systems

Figure 4

Viral replication after hydrodynamic transfection in mice model.

Mice were injected hydrodynamically with 10 μg pHBV4.1, pHBV-rtA181T/sW172* and pHBV-rtA181T/sW172L respectively, and were sacrificed at different time points. (A) HBV DNA replication intermediates of mice livers were detected by Southern blotting. (B) Quantitative analysis of HBV DNA replication intermediates. The level of HBV DNA replication intermediates in pHBV4.1 group 3 days after infection was defined as 1. The mean HBV DNA levels plus standard deviation from three independent analyses were also shown, and the P values were determined using Mann-whitney U test.

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