Figure 3 | Scientific Reports

Figure 3

From: Altered systemic bile acid homeostasis contributes to liver disease in pediatric patients with intestinal failure

Figure 3

Pediatric IF patients exhibit impaired activation of intestinal FXR/FGF19 axis.

(A) Immunohistochemical (IHC) analysis for CD3 and FXR in ileal tissues from patients (n = 7) and controls (n = 6). (B,C) Quantification of CD3 IHC and FXR IHC. (D,E) CD3 IHC conversely correlated with FXR IHC and serum FGF19 concentrations. Scale bar = 50 μm. *p < 0.05; **p < 0.01.

Back to article page