Figure 4 | Scientific Reports

Figure 4

From: Altered systemic bile acid homeostasis contributes to liver disease in pediatric patients with intestinal failure

Figure 4

Decreased FGF19 impaired CYP7A1 expression in liver.

(A–C) Altered BA composition in liver tissues. (D–F) Serum FGF19 levels inversely correlated with primary bile acids including CA, CDCA and GCA in liver (Control, n = 5, Patients, n = 5) (G) FXR and CYP7A1 IHC. (H,I) Quantification of panel G. (J) Western-blot analysis for FXR and CYP7A1. (K) The scheme illustrates a potential mechanism by which FGF19 contributes to development of IFALD. Scale bar = 50 μm. *p < 0.01.

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