Table 2 Liver biochemistry, serum lipids, glucose and inflammatory cytokines in the patients.
Variable | Control | Patients | p value | Correlation with FGF19 | |
|---|---|---|---|---|---|
n = 21 | n = 23 | Control vs. patients | r | p value | |
Liver enzymes | |||||
Plasma alkaline phosphatase, ALP (U/L) | 51.76 ± 69.24 | 90.34 ± 66.99 | 0.08 | −0.34 | 0.03 |
Plasma alanine aminotransferase, ALT (U/L) | 23.23 ± 16.01 | 55.77 ± 19.91 | <0.01 | −0.19 | 0.24 |
Plasma aspartate aminotransferase, AST (U/L) | 36.35 ± 16.66 | 61.67 ± 27.51 | <0.01 | −0.3 | 0.06 |
Markers of cholestasis | |||||
Plasma total bilirubin (μmol/L) | 5.33 ± 2.55 | 6.24 ± 1.35 | 0.15 | −0.15 | 0.37 |
Plasma conjugated bilirubin (μmol/L) | 3.16 ± 1.43 | 3.19 ± 2.26 | 0.97 | −0.07 | 0.67 |
Serum lipids | |||||
Serum HDL cholesterol (mmol/L) | 0.76 ± 0.26 | 0.63 ± 0.19 | 0.09 | 0.07 | 0.64 |
Serum LDL cholesterol (mmol/L) | 1.50 ± 0.56 | 1.83 ± 0.45 | 0.04 | 0.02 | 0.92 |
Serum total cholesterol, TC (mmol/L) | 2.00 ± 0.47 | 2.4 ± 0.61 | 0.02 | −0.16 | 0.32 |
Serum triglycerides, TG (mmol/L) | 0.79 ± 0.31 | 1.13 ± 0.60 | 0.03 | 0.08 | 0.6 |
Plasma glucose (mmol/L) | 3.80 ± 1.16 | 3.21 ± 0.88 | 0.21 | 0.18 | 0.26 |
Markers of inflammation | |||||
Serum IL-6 (pg/mL) | 13.28 ± 21.78 | 50.63 ± 45.99 | <0.01 | −0.32 | 0.04 |
Serum TNF-α (pg/mL) | 0.41 ± 0.2 | 0.89 ± 0.43 | <0.01 | −0.33 | 0.32 |
