Figure 3 | Scientific Reports

Figure 3

From: PD-L1+MDSCs are increased in HCC patients and induced by soluble factor in the tumor microenvironment

Figure 3

Soluble factors from HCC played an important role in the differentiation of PD-L1+MDSCs.

(a) This is a schematic diagram of the transwell coculture system. Upper image shows a normal coincubation and lower image shows a coincubation using a neutralizing antibody. (b) The percentages of PD-L1+MDSCs were significantly increased after 72 hours coincubation with several cancer cell lines compared with control, primary hepatocyte and other cancer cell lines. (c) A part of the ImMCs showed a phenotype similar to MDSCs after coincubation with ImMCs and cancer cell lines. (d) The percentages of PD-L1+MDSCs under the stimulation of recombinant human M-CSF or VEGF were significantly higher than in those without cytokine stimulation.

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