Figure 6 | Scientific Reports

Figure 6

From: Surfactin inducing mitochondria-dependent ROS to activate MAPKs, NF-κB and inflammasomes in macrophages for adjuvant activity

Figure 6

Surfactin inducing macrophages apoptosis.

(A) Mice were stimulated with SFN (100 μg/mouse) in vivo, then the apoptosis of peritoneal macrophages was determined by staining with Annexin V-FITC and PI. (B) The percentage of Annexin V-FITC-stained cells (early apoptotic cells) was significantly higher than the untreated control at the time points of 4 h and 12 h. Post administration more than 12 h, the lately apoptotic cells (stained by Annexin V-FITC and PI) significantly increased when compared to untreated group. Double stars (p < 0.01) and single star (p < 0.05) mean the significant difference between SFN treatment and untreated.

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