Figure 6 | Scientific Reports

Figure 6

From: Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases

Figure 6

SMP30 deficiency exacerbates pulmonary emphysema and dysfunction in C57/BL6J-βENaC-Tg mice.

(a) Scheme of the generation of C57/BL6J-βENaC-Tg-SMP30 KO mice. (b,c) Serum levels of oxidative stress in C57/BL6J-βENaC-Tg and C57/BL6J-βENaC-Tg-SMP KO mice ((b), male; (c), female). n = 3–7 mice/group. *p < 0.05, versus C57/BL6J-Tg (Y/+) mice; Student’s t test. #p < 0.05, #p < 0.01, versus C57/BL6J-βENaC-Tg (+/+) mice; Dunnett’s test. (d–i) Pulmonary phenotypes were evaluated in male (d–f) and female (g–i) C57/BL6J-βENaC-Tg and C57/BL6J-βENaC-Tg-SMP KO mice. Emphysematous phenotypes (d,e,g,h) and pulmonary dysfunction (f,i) of the mice were evaluated. n = 6 mice/group. *p < 0.05, **p < 0.01, versus C57/BL6J-βENaC-Tg (Y/+) mice; Student’s t test. #p < 0.05, ##p < 0.01, versus C57/BL6J-βENaC-Tg (Y/+) mice; Dunnett’s test.

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