Figure 7 | Scientific Reports

Figure 7

From: Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases

Figure 7

Effect of serine protease inhibition and VC depletion on the expression levels of mucus-related and inflammatory genes in C57/BL6J-βENaC-Tg mice.

Pulmonary mRNA expression of KC (a,d,g), Gob5 (b,e,h) and Muc5ac (c,f,i) genes in WT and C57/BL6J-βENaC-Tg mice treated with vehicle (CON), CM or ONO-3403 (a–c) (n = 6–7 mice/group), and C57/BL6J-βENaC-Tg and C57/BL6J-βENaC-Tg-SMP KO mice ((d–f), male; (g–i), female) (n = 4–6 mice/group) quantified by Q-RT-PCR. *p < 0.05, versus WT; Student’s t test. #p < 0.05 versus vehicle-treated C57/BL6J-βENaC-Tg mice; Dunnett’s test. $p < 0.05, $$p < 0.01, versus C57/BL6J-βENaC-Tg (Y/+) or (+/+) mice; Dunnett’s test.

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