Figure 2
From: TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis
Involvement of GEF-H1 in TRPC3-mediated cardiac fibrosis in pressure overloaded mouse hearts.
(a) Activation of RhoA in TRPC3(+/+) and TRPC3(−/−) mouse hearts 1 week after TAC (n = 3). (b) Representative image of SYPRO Ruby staining of gels loaded with RhoAG17A-pulled down proteins. Fibroblasts were stimulated with TGF-β2 (2 ng/mL) for 6 h. (c) Activation and expression of GEF-H1 in mouse hearts 1 week after TAC (n = 3). (d) Expression of LARG in mouse hearts 1 week after TAC (n = 3). Error bars, s.e.m. *P < 0.05, **P < 0.01.
