Table 2 Methodological quality of case-control studies in our meta-analyses, based on the Newcastle–Ottawa Scale.

From: Genetic polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 promoter may not be associated with development of hepatocellular carcinoma

Study

Selection (score)

Comparability (score)

Exposure (score)

Adequate definition of patient cases

Representativeness of patients/cases

Selection of controls

Definition of controls

Control for important factor or additional factor

Ascertainment of exposure (blinding)

Same method of ascertainment for participants

Non-response ratea

Total scoreb

Migita et al.12

1

1

0

1

0

0

1

1

5

Kim et al.13

1

1

0

1

0

0

1

1

5

Chen et al.14

1

1

1

1

1

0

1

1

7

Teixeira et al.15

1

1

1

1

0

0

1

1

6

Karra et al.16

1

1

0

1

0

0

1

1

5

Bao et al.17

1

1

1

1

2

0

1

1

8

Zhang et al.18

1

1

1

1

2

0

1

1

8

Lau et al.19

1

1

0

1

1

0

1

1

6

  1. aOne point was awarded when there was no significant difference in the response rate between both groups based on the chi-squared test (P > 0.05).
  2. bCalculated by adding up the points awarded for each item.